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Abstract: The article deals with the problem of mutations of meaning in the semantic structure of verbs in the process of prefixation. It focuses on the peculiarities of mutation processes in the structure of verbs belonging to the same lexico-semantic group (LSG). Analysis of the definitions found in lexicographical resources makes it possible to single out two types of mutation: transmutation and reflected mutation. Modified meaning is treated as a meaning which forms on the basis of the original (producing) meaning by changing this meaning in various ways, and mutation is aimed at a radical change in its inner structure. The article studies verbal mutation which causes such a change that a word-building element modifies the lexico-semantic structure of the original stem and, as a result of this change, leads to the appearance of a new component in the structure of the derived stem. Mutation (inner word mutation), or transmutation is found when original (primary) meanings of polysemantic verbs are connected with other lexico-semantic classes of verbs. R. Jakobson was the first to use the term “transmutation” to indicate intersemiotic translation, i.e. transfer of a phenomenon from one linguistic system to another, rather than use this term to denote a transfer of a word from one lexicosemantic environment (original domain) into a new one, originally not characteristic of it. Transmutation Involving one of the meanings of a polysemantic non-derived verb may have a certain effect on some lexico-semantic variants of the derivatives. This effect is often called “reflected mutation”. The notion of reflected mutation easily conforms to the better known and broader notion of reflected polysemy, as in accordance with its essence it can be viewed upon as a particular case of reflected polysemy, which is often associated with the original semantic field where the sum total of all lexical meanings of the motivator has a word-building reflection in the derivative.