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Abstract: Many researchers come to the conclusion that universities should become knowledge generators. Building a digital economy is designed to ensure, on the one hand, more efficient and less costly economic functioning, on the other – a radical change in the relationship between society, the state and business. This involves the organization of training aimed at the effective use of modern information and communication technologies related to the introduction of artificial intelligence and robotics, based on the formation of new thinking and working style. At the same time, a serious problem in the implementation of digital economy initiatives is personnel training, which in turn determines the role and importance of education in this process. The purpose of the article is to identify and study the main factors that affect the process of transformation of Russian regional universities, based on the study of Russian literature. The scientific novelty of the article is the definition of digital transformation of the educational process as a creative system of relations between its participants and stakeholders, formed as a result of the development and implementation of modern information technologies and corresponding communication devices in the learning process, the end result of which will be the creation of a model of a “digital university” as a set of regulatory requirements for the digital environment of the University. As a result, the study analyzes the main directions of digital transformation of the educational process in higher education, including the formation of an integrated environment, the development of online education, the use of domestic and foreign digital platforms, innovative educational components, retraining and advanced training of teachers in relation to digital formats of the learning process.